🚨 New Modulus Therapeutics Preprint 🚨 We've been really interested in reprogramming cell function in response to diverse environmental signals. In this new preprint, we describe our workflow for finding novel switch receptor designs, and how a comprehensive exploration of signaling space yields functions that would be nearly impossible to intuit or design by hand. https://lnkd.in/gCigviZJ Some highlights: - Switch receptors classically convert 'negative' extracellular signals to 'positive' signals. Here, however, we show that this behavior is much more analog than digital. Tuning specific signaling domain combinations yields a spectrum of function across multiple axes such as cytotox and persistence. - To our knowledge, this is the largest pooled screen ever done in NK cells, at 11,131 members, all in primary cells, using functional assays converted to be screening-compatible. - We observe hits from a diverse set of receptor domains, including cytokine receptor domains, and even receptors classically thought of as inhibitory, suggesting that 'tuning' of cell function via signaling is a lot more nuanced than expected if one merely puts receptors into coarse-grained buckets. Hats off to an amazing team that went from zero-to-one on this whole concept incredibly quickly! #celltherapy #nk #syntheticbiology #oncology #autoimmunedisease
Modulus Therapeutics
Biotechnology Research
Seattle, WA 1,047 followers
Transforming Cell Therapy
About us
Modulus is engineering next-generation immune cell therapies, starting with Natural Killer cells rationally designed for the treatment of solid tumors. Modulus’ Convergent Design™ platform combines genetic engineering, machine learning, and high-throughput in vivo screening to systematically converge on optimized cell designs. Modulus is committed to the discovery of cell therapies to treat a broad set of patient populations not currently served by existing treatments and will use its platform to enable partners and develop an internal pipeline of therapeutics.
- Website
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http://www.modulustherapeutics.com
External link for Modulus Therapeutics
- Industry
- Biotechnology Research
- Company size
- 2-10 employees
- Headquarters
- Seattle, WA
- Type
- Privately Held
- Founded
- 2020
Locations
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Primary
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Seattle, WA 98103, US