Macrophage overview

macrophage

Function

Macrophages are tissue-resident or infiltrating immune cells critical for innate immunity, normal tissue development, and repair of damaged tissue. Macrophages’ function is a result of their original designation, their local micro-environment, and the type of metabolites, substances or pathogens to which they are exposed.

macrophage

Disfunction

Reprogrammed out of their homeostatic state, macrophages contribute to the pathophysiology of multiple diseases including cancer and various inflammatory disorders.

Allocetra represents a paradigm shift in macrophage reprogramming,
moving from a binary classification of M1 or M2 status,
to a holistic view of Macrophage Homeostasis

Solid cancer

Macrophage homeostasis can be effected through multiple functionality axes

solid cancer
Survival
solid cancer

Recruitment
into TME

solid cancer

Anti-cancer
activity

Proliferation

Non-homeostatic, pro-tumor macrophages (TAMs) can be killed, inhibited or reprogramed through multiple pathways

tams

Allocetra provides a radically-diferent alternative to macrophage reprogramming in cancer.

Sepsis

Outcomes of negative macrophage reprogramming resulting in lack of homeostasis

homeostasis